Multifunctional silk fibroin – Poly(L-lactic acid) porous nanofibers: Designing adjustable nanopores to control composite properties and biological responses

Nano-scale renewable porous materials have a wide range of applications in the biomedical field such as tissue engineering and biosensors due to their high biocompatibility large surface area. In this study, composite silk fibroin poly(L-lactic acid) was electrospun together form nanofiber biomaterial with 11 blending ratios tune porosity single fibers (19.3–49%). This is highly advantageous effectively promoted cell attachment proliferation while also manipulating growth. The protein-polymer molecular interactions, structures crystal contents, well melting glass transition behaviors composites were determined. Results reveal that varying content can directly nanopore structure each individual fiber. nanofibers much higher thermal stability when compared pure or PLA nanofibers. Besides, SF concentration increased from 0% 100%, hydrophilicity (contact angle decreased 135° 103°), enzymatic degradation residues 20% 95%. study provides unique method for tuning nano-fabrication properties be widely useful fields biomedicine sustainable materials.